Today stress is a part of our daily life, demonstrating itself in some cases as an element for the overall look of conditions such as depression.
Depression is characterized by that the World Health Organization as a frequent mental disorder, characterized by the existence of both despair, loss of interest or pleasure, feelings of guilt or lack of self-esteem, sleep or appetite disorders, sense of tiredness, and lack of concentration.
Major patients become overwhelmed with negative emotions and prevent for no apparent reason. These symptoms could also lead to a myriad of fitness complications ( sleeplessness, overfeeding, bulimia, body aches, and heart attacks ), all of which can have severe repercussions on the individual’s everyday life.
Depression is not a condition that somebody you can simply”get out”. Especially in those people whose symptoms are imperceptible overseas.
So a year ago a social campaign was launched on different social networks using the hashtag #despessionhasnoface (depression has no face) where people told their stories, initiated after the tragic suicide of Chester Bennington – lead singer of this American band Linkin Park. This effort revealed a high amount of individuals considered the indicators of anxiety and despair to be momentary and temporary, leaving those emotions to collect without being able to obtain the source of those.
They use different medicines, such as strong antidepressants, to attempt to relieve distress and sadness, but this method might have serious side effects and due to the compound nature of this form of medicine, it is not too easy or quick to stop taking antidepressants. As an alternative strategy, the usage of all CBD merchandise has been recognized: oil, infusions, patches. The effect of these products is recognized against stress and as stated by the consumers of these, cannabidiol has a positive influence on individuals suffering from depression.
The fact that CBD helps for stress and anxiety was previously recognized in one of our articles where we clarify the anxiolytic effects of this chemical, reported in a study by Campos and his group at the Federal University of Minas Gerais, Brazil: CBD is a secure compound with a large assortment of therapeutic uses, including the treatment of psychiatric disorders. These discoveries make this medication an attractive candidate for prospective clinical trials.”
How many men and women suffer from depression?
According to the WHO (World Health Organization) in Spain, over 2.4 million inhabitants suffer from depression, a total of 5.2percent of the populace (data collected in 2015). According to his account, the incidence of this disease has increased by 18.4percent in the previous decade.
What causes depression?
Scientists at Harvard University have used advanced brain imaging, such as PET scans and functional MRI scans, to get a closer look at the internal workings of their brains. The usage of complex technology has resulted in a better understanding of the extent to which brain imbalances have from the manifestation of depression.
The regions of the mind that play a significant role in depression are the amygdala, the thalamus, and the hippocampus.
Depression and mind imbalances
Harvard researchers are trying to connect the dots between the slow generation of neurons in the hippocampus component of their minds and feelings of depression. This theory is supported by how antidepressants operate: Specialty medication instantly increases the number of neurotransmitters in the brain, slowly improving the individual’s mood. But if depression were only the result of brain chemical imbalances, then people would feel better instantly after receiving the medicine.
How is depression diagnosed?
Depression may be diagnostic to by a licensed professional who can determine if someone is suffering from depression through counseling. This necessitates that the individual is open about their experiences and ready to accurately describe their symptoms. Depressed people often feel that they are not sick, or that there is no treatment for their condition. Although in most instances there are no physical examinations for depression, psychiatrists may need some tests to rule out conditions such as thyroid disease.
How is depression treated?
The most common remedies for depression are via medication or psychotherapy. Both of these are often used together and produce positive outcomes. Essentially, psychotherapy reduces negative thought patterns that perpetuate depression, whilst medication tries to balance hormonal action in the mind. It is strongly recommended that people with depression remain physically active, as exercise naturally increases serotonin levels in the brain. Studies have shown that physical activity can be as successful as medicine in regulating the signs of severe depression.
Does CBD Help Treat Depression?
As research on the effects of CBD accumulation, it was merely a matter of time until the medical community started to inquire into the potential for using CBD as a remedy for depression. In 2014, a study completed with animal models showed that CBD has significant antidepressant and anxiolytic properties. Laboratory mice failed a succession of tests and the results showed that when treated with CBD, the subjects demonstrated fewer instances of depression and anxiety. There’s no conclusive evidence that CBD could have a Positive Effect on depression, however, studies show that the use of CBD can
Affect serotonin levels within the body and improve sleep patterns. Research on the connection between depression and physical symptoms has proven that depression and pain share a common recurrence pathway influenced by dopamine and norepinephrine. Past research has proven that CBD has antidepressant effects that trigger the release of anandamide, a neurotransmitter responsible for controlling serotonin levels within the human body.
It appears that the CBD has a future beyond the management of inflammation or chronic pain. It is only a matter of time before all of the research protocols that specifically support CBD as a related antidepressant therapy come to light, even reducing the use of current artificial components for treating this illness.
CBD oil has many applications – it’s used to alleviate inflammation and pain and can be a trusted relaxation treatment after a stressful day.
CBD owes this ability to its formidable anti-inflammatory advantages.
As we’ll see in more detail below, inflammation is a key underlying cause of depression.
By helping us overcome systemic inflammation and low-grade neuroinflammation, CBD can do a lot to alleviate chronic depression.
Pharmaceutical treatments for depression
Depression treatment involves finding the cause.
Psychologists will generally identify if there are signs of misuse, personal issues, stressful events, chemical abuse, or other causes of depression that may be at stake.
Dietitians, nutritionists, and natural health therapists will examine diet and consider the way the lifestyle of these influenced harms their depression.
Oftentimes, a diet and a change in lifestyle are sufficient to alleviate most symptoms of depression.
Doctors treat depression as an imbalanced condition. You will be given medications such as monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants (TCAs), and selective serotonin reuptake inhibitors (SSRIs) to counter this.
1. MAOI (monoamine oxidase inhibitors)
MAOIs are a category of pharmaceutical medications used to treat depression.
It involves inhibition of this enzyme (monoamine oxidase) that breaks down monoamine neurotransmitters (dopamine, serotonin, norepinephrine).
By blocking this receptor, dopamine, dopamine, and norepinephrine requires more time to break down, and so persist in neurons for longer periods of time.
If the cause of depression is a low serotonin or dopamine level, this class of compounds is useful for increasing activity and relieving symptoms. But it will not address the issue because, as soon as you stop taking the medicine, everything returns to normal. In some cases, we’ve rebound drops of dopamine and serotonin, causing much more acute symptoms.
2. SSRIs (selective serotonin reuptake inhibitors)
This is the most frequent class of antidepressants used now.
Low serotonin levels are considered by many to be the most important reason for depression. So if there was a method to specifically target this neurotransmitter to boost its activity in the mind, we could alleviate the symptoms of depression.
A selective serotonin reuptake inhibitor functions to block the reabsorption of dopamine and its dissolution at synapses in the brain.
This causes serotonin to build up outside the synapses, thus improving general disposition.
It’s very important to be aware that SSRIs don’t resolve the reason for low serotonin, and there is a lot of evidence to support that most cases of depression do not involve dopamine lack. Instead, the study now points to the idea that depression is the direct result of neuroinflammation.
This explains why SSRIs have less effect on people as inflammatory markers increase in the bloodstream.
3. Tricyclic antidepressants
- Tricyclic antidepressants are an older generation of antidepressant drugs.
- They’ve been replaced with newer versions, such as graphics and SSRIs.
- They block the reabsorption of serotonin and norepinephrine, which makes them quite similar to SSRIs.
- The difference is that tricyclic antidepressants also generate a variety of unwanted side effects on other hormones, providing them inconsistent side effects.
Does the chemical imbalance cause depression?
The suggestion that depression is the result of neurotransmitter dysfunctions, which generally involve melatonin, is over 50 years old.
Research has come to away since then, especially within the specialty of neurology.
Although many doctors adhere to the idea that depression is brought on by low levels of hormones, this is significantly simplified and there are no clear connections between both.
The evidence to support this concept involves something related, known as tryptophan depletion. In this procedure, the precursor to serotonin, tryptophan, is entirely blocked, causing serotonin levels to fall and depressive symptoms to appear.
The healthy peoples, the depletion of tryptophan does not cause depression. This only happens in people that are predisposed to manic symptoms.
Drugs that target serotonin levels are currently the main remedy for depression, nevertheless they do not have a higher success rate.
A typical underlying reason for depression
- Our half-century-old comprehension of depression is now beginning to change.
- More research is published annually that suggests the main cause of depression is neuroinflammation.
- Essentially, this means”inflammation of the brain.”
This makes great sense because neuroinflammation is connected to reduced serotonin levels, inadequate access to nutrients in the mind, and enhanced oxidative damage.
If this were accurate, wouldn’t decrease inflammation relieve depression symptoms?
Anti-inflammatory medications for depression
Looking outside of mainstream medicine, which maintains its obsession with serotonin levels, there are many other ways to effectively tackle depression.
From the sphere of botanical medicine, there are maybe hundreds of remedies for depression, a few of which can be traced back to the modulation of neurotransmitters, such as St. John’s wort or even Catuaba, but others have a less noticeable mechanics (initially).
Ashwagandha, Rehmannia, ginseng, turmeric, and frankincense are powerful antidepressants with abundant evidence to support their use, but none of them have a very clear interaction with dopamine. The factor that connects these herbs is the strong anti-inflammatory profile.
You can find different examples of reliable antidepressant herbs with anti-inflammatory effects, too many to list here, actually.
Conventional medicine is catching up, and there are a number of anti-inflammatory drugs being tested for the treatment of depression, some of which show promising results.
How are cannabis and CBD related to all of this?
CBD is arguably one of the strongest herbal anti-inflammatory substances on Earth.
CBD stands for cannabidiol. It is simply one of approximately 60 distinct compounds collectively called cannabinoids.
These are special chemical compounds found in the cannabis plant that interact with our endocannabinoid system. This is a system of receptors and hormones that help regulate a number of important processes in the body, for example, neurostimulation, hunger amounts, and sexual functioning.
CBD is the primary non-psychoactive cannabinoid. Another principal cannabinoid, THC, is responsible for its adverse consequences attributed to bud and the euphoria it produces.
Since CBD isn’t psychoactive, it may be obtained during the day without causing changes in cognition. It’s used to alleviate inflammation, pain, and nervousness, and even to relieve many of the major symptoms associated with depression.
Use CBD for depression
With over 60 distinct cannabinoids, countless different terpenes, and many other substances, it can be difficult to identify the mechanism behind the cannabis plant which treats depression.
However, CBD is unquestionably one of the very best candidates and there are a variety of studies supporting it for this application.
There are a few ways CBD can relieve symptoms of depression, such as increasing serotonin levels and decreasing pain; however, the most crucial thing is its role in reducing inflammation.
CBD and inflammation
There are hundreds of different inflammatory mediators in the human body.
The inflammation that results from conditions like arthritis, IBS, traumatic injury, or autoimmunity is different. Something which may work for you can do nothing for others.
CBD is exceptional in that it offers its anti-inflammatory advantages in almost all sorts of inflammation, such as neuroinflammation associated with depression.
In total, CBD was proven to block vital inflammatory mediators PGE2, COX (cyclooxygenase), the creation of free radicals, and nitric oxide.
This makes it useful for decreasing overall inflammation throughout the body, for example, intestine, skin, various organs, the cardiovascular system, and the brain.
This is considered the key therapeutic mechanism behind CBD’s antidepressant action, as well as many of its common applications, such as pain loss, arthritis, and autoimmune disease.
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